In 1543, Vesalius published the groundbreaking , an anatomy text based mostly on human dissection. His work transformed anatomy into a subject that relied on observations taken directly from human dissections. Vesalius eventually left anatomical research to take up medical practice, becoming physician to the imperial court of Emperor Charles V. In 1555, he went into service for Charles' son, Philip II of Spain. In 1564, he travelled to the Holy Land but died on 15 October 1564 on the Greek island of Zakynthos during the journey home.


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