Although natural hallucinogenic drugs have been known to mankind for millennia, it was not until the early that they received extensive attention from . Earlier beginnings include scientific studies of nitrous oxide in the late , and initial studies of the constituents of the peyote cactus in the late 19th century. Starting in with 's (The Mescaline Intoxication), more intensive effort began to be focused on studies of psychoactive plants. Around the same time, Louis Lewin published his extensive survey of psychoactive plants, (1928). Important developments in the years that followed included the re-discovery of (in by Robert J. Weitlaner) and (in by ). Arguably the most important pre-World War II development was by 's invention of the semi- drug LSD, which was later discovered to produce hallucinogenic effects, in .


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